Hollow fibre bioreactors are the ultimate solution to high density continuous culture.

The bioreactor is inoculated at 5 million/ml and reaches a density of
200-400 million/ml after 1-2 weeks with average cultures running for
60-90 days, although much longer cultures are not uncommon.

As a result hollow fibre systems provide a compact, efficient, stable
and economic method of producing biologicals.

Process Advantages: 100 fold less growth supplement usage than STR Superior harvests: mgs/ml and cell free High density culture:>108 cells/ml Suspension or adherent cell lines Benefits: Reduced media costs Simplified post-processing – No concentration step – No clarification step Variety of cell lines

Facility Advantages: Simple 240 VAC and 100% CO2 No CIP/SIP skids large suites Easy seed train 1,600L - equivalent fed batch in 1.2m2 Equipment mobility and flexibility Benefits: Complete IQOQ <1 Week Reduced Costs – Fixed, operating and maintenance Easy operation Permits flexible campaigning